Tissue Factor Pathway Inhibitor

Tissue factor pathway inhibitor (TFPI) is an anticoagulant protein that inhibits early phases of the procoagulant response. Inhibiting TFPI restores thrombin generation activity.   This website provides further information on the role of TFPI in the anti-coagulation pathway.

TPFI as a Molecular Target

 

Other resources

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Tissue Factor Pathway Inhibitor

Tissue factor pathway inhibitor (TFPI) is an anticoagulant protein. It is found in plasma, platelets and the extracellular matrix, and on endothelial cells, monocytes and macrophages. TFPI fulfils its important role as a regulator of bleeding in haemophilia by inhibiting proteases at several steps of coagulation to reduce procoagulant stimuli. This reduces thrombin generation and diminishes initiation of coagulation.1

 

This video explores in detail the role and mechanism of TFPI in the coagulation pathway.

TFPI MoA (Subtitles: Arabic)

TFPI MoA (Subtitles: French)

TFPI MoA (Subtitles: Spanish)

TFPI MoA (Subtitles: Deutsch)

TFPI MoA (Subtitles: Japanese)

TFPI MoA (Subtitles: English)

TFPI MoA (Subtitles: Russian)

Other resources:

 

What is TFPI?

Pools of TFPI

Rationale for blocking TFPI in haemophilia

For further reading:

Targeting TFPI for hemophilia treatment - PubMed (nih.gov)

 

Anti-tissue pathway inhibitor (TFPI) therapy: a novel approach to the treatment of haemophilia - (nih.gov)

 

Regulation of coagulation by tissue factor pathway inhibitor: Implications for hemophilia therapy - PubMed (nih.gov)

1. Mast AE, Ruf W. J Thromb Haemost. 2022;20(6):1290–1300.

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